A number is divisible by 5 iff it ends with either 5 or 0. So you know right away that 123·345=42434 is wrong. It's a different question how to get the right answer (42435).
Use divisibility criteria.
As above, divisibility criteria are useful in establishing whether a result is wrong. Note that this way you never may be sure whether the result is right. The following criteria is available:
A number is divisible by 4 iff its 2-digit
tail is divisible by 4. For example, 12345 is not divisible by 4 since 45 is not. However,
12348 is divisible by 4 since 48 is.
A number is divisible by 8 iff its 3-digit
tail is divisible by 8. For example, 12345 is not divisible by 8 since 345 is not. However,
12344 is divisible by 8 since 344 is. Indeed 344=320+24, where both operands are divisible by 8.
A number is divisible by 25 if it ends with one of the four: 00, 25, 50, 75. Therefore
234465 is not divisible by 25.
The is a general way of deriving divisibility criteria for numbers such as 7, 11, 13, and other.
Use rude bounds.
127·345=27455 is clearly wrong because 127>100 while 345>300. Therefore, it must be that
127·345>100·300=30000.
220=524288 is clearly wrong because 220=(210)2=10242>10002=1000000.
Actually 524288=219.